Relationship between Platelet–Lymphocyte Ratio and Lung Lesion Area in Pulmonary Tuberculosis Patients at Abdul Moloek Regional Hospital in 2023-2024
DOI:
https://doi.org/10.53366/jimki.v12i3.1021Keywords:
Lung Lesion Area, Platelet–lymphocyte ratio, Pulmonary TuberculosisAbstract
Background:. Pulmonary tuberculosis remains a major health problem and requires a simple marker to assess disease severity. The platelet-lymphocyte ratio (PLR) has been widely studied as an indicator of inflammation, but its relationship with lung lesion extent remains inconsistent. This study aimed to assess the relationship between PLR and lung lesion extent in pulmonary tuberculosis patients at Abdul Moloek Regional Hospital. Methods: This study used a cross-sectional design with a total sampling technique. A total of 52 patients who met the inclusion and exclusion criteria were analyzed. PLR data were obtained from complete blood counts, and lesion extent was assessed using chest radiography. Spearman correlation analysis was used to test the relationship between the two variables. Results: The distribution of lesion extent showed the largest proportion in the extent category. PLR values ??varied significantly between subjects. The Spearman test showed a correlation coefficient of 0.084 with a p-value of 0.553, indicating no significant relationship between PLR and lung lesion extent. Conclusion: This study concluded that PLR is not associated with lung lesion extent in pulmonary tuberculosis patients. PLR cannot be used as a radiological marker to assess the severity of lung damage, so additional parameters or a multimodal approach are needed in clinical evaluation
References
. WHO. Global Tubercolosis Report 2023.; 2023. https://www.who.int/publications/i/item/9789240083851
2. Saktiawati AMI, Probandari A. Tuberculosis in Indonesia: challenges and future directions. Lancet Respir Med. 2025;13(8):669-671. doi:10.1016/S2213-2600(25)00168-7
3. APCASO. The Struggle With Climate And Health Crises.; 2025. https://apcaso.org/wp-content/uploads/2025/10/Climate-Stories_Indonesia.pdf
4. WHO. The Second National TB Inventory Study in Indonesia.; 2024. https://www.who.int/teams/global-programme-on tuberculosis-and-lung-health/tb-reports/global-tuberculosis-report-2024/featured-topics/the-second-national-tb-inventory-study-in-indonesia
5. Lampung Satu Data. Tren Cakupan Penemuan Kasus Tuberkulosis (Case Detection Rate) (%) Provinsi Lampung Tahun 2021-2024.; 2024. https://opendata.lampungprov.go.id/dataset/tren-cakupan-penemuan-kasus-tuberkulosis-case-detection-rate-provinsi-lampung-tahun-20212024
6. Mustofa, S., Ananta, Y., Ginting, B., Septiani, L., & Busman, H. (2025). A Case Report: Multidrug-Resistant Tuberculosis in A 53-Year-Old Patient. Jurnal Ilmu Kedokteran dan Kesehatan, 12(2), 386-392
7. Rees CA, Pineros DB, Amour M, et al. The potential of CBC-derived ratios (monocyte-to-lymphocyte, neutrophil-to-lymphocyte, and platelet-to-lymphocyte) to predict or diagnose incident TB infection in Tanzanian adolescents. BMC Infect Dis. 2020;20(1):609. doi:10.1186/s12879-020-05331-w
8. Xu R, Chen L, Yan C, Xu H, Cao G. Elevated Platelet‐to‐Lymphocyte Ratio as a Predictor of All‐Cause and Cardiovascular Mortality in Hypertensive Individuals. J Clin Hypertens. 2025;27(1). doi:10.1111/jch.14980
9. Kirwan DE, Chong DLW, Friedland JS. Platelet Activation and the Immune Response to Tuberculosis. Front Immunol. 2021;12. doi:10.3389/fimmu.2021.631696
10. He X, Hou H, Jiang Y, Huang X. Association Between Indices of Peripheral Blood Inflammation and Cavitary Pulmonary Tuberculosis. Int J Gen Med. 2024;Volume 17:5133-5142. doi:10.2147/IJGM.S483185
11. Nguyen-Huu CD, Tran THC, La THN, Nguyen VT. Hematological parameters in pediatric pulmonary and extrapulmonary tuberculosis in Vietnam: a prospective observational study. Egypt Pediatr Assoc Gaz. 2025;73(1):4. doi:10.1186/s43054-025-00345-y
12. Oza D, Luhadia A, Patel VK, Ahluwalia R. Exploring the relationship between neutrophil-lymphocyte ratio (NLR), body mass index (BMI), and treatment outcomes in pulmonary tuberculosis. Indian J Tuberc. Published online February 2025. doi:10.1016/j.ijtb.2025.02.009
13. Mustofa S, Putri NSPDL, Togihon L, Aryana WF, Sanjaya RP, Saputra TT. 2023. Laporan Kasus: Bronkiektasis Terinfeksi Disertai Sindroma Obstruksi Pasca Tuberkulosis. Majority. 12(1): 33–42.
14. Liu QX, Tang DY, Xiang X, He JQ. Associations between nutritional and immune status and clinicopathologic factors in patients with tuberculosis: A comprehensive analysis. Front Cell Infect Microbiol. 2022;12. doi:10.3389/fcimb.2022.1013751
14. J NH, Venkataraman A, Thiruvengadam K, et al. Evaluation of platelet indices as markers of tuberculosis among children in India. ERJ Open Res. 2024;10(1):00734-02023. doi:10.1183/23120541.00734-2023
15. Kumar SR, Kandhasamy C, Velayutham VB, et al. Hematological Parameters in Patients with Pulmonary Tuberculosis and its Presentation among Favorable and Unfavorable Treatment Outcomes. Indian J Public Health. 2024;68(3):362-365. doi:10.4103/ijph.ijph_918_23
16. Ali A, Wu L, Moazen EM, et al. Hematological profiles and mortality risk in critically ill and drug-resistant tuberculosis patients: insights from a longitudinal study. Egypt J Bronchol. 2024;18(1):40. doi:10.1186/s43168-024-00294-x
17. Mustofa, S., Megantoro, G. K., Gozali, A., Saputra, T. T., & Sanjaya, R. P. (2023). Sindrom Obstruksi Pasca Tuberkulosis Dengan Luluh Lobus: Laporan Kasus. Jurnal Ilmu Kedokteran dan Kesehatan, 10(7), 2426-2430.
18. Zain Z. HUBUNGAN HASIL PEMERIKSAAN MIKROSKOPIS TB DENGAN PROFIL HEMATOLOGI PADA PENDERITA TUBERKULOSIS PARU DI PUSKESMAS PANJANG KOTA BANDAR LAMPUNG. Poltekkes Tanjungkarang.; 2022.https://repository.poltekkes-tjk.ac.id/id/eprint/3976/
19. Karwiti W, Lestari WS, Rezekiyah S, Jambi PK. PERBEDAAN PROFIL HEMATOLOGI PADA PENDERITA TUBERKULOSIS PARU YANG MENJALANI PENGOBATAN. 2021;3(1):126-132.
20. Rahmayanti S, Parinding JT, Tasya, Satriadi R, Ysrafil. HUBUNGAN HEMATOKRIT, TROMBOSIT DAN RASIO TROMBOSIT LIMFOSIT DENGAN LAMA RAWAT PADA PASIEN DBD ANAK. J Vokasi Kesehat. 2021;7(1):24-29.
21. Ramadhian, M. R., Nadhifa, F., Nareswari, S., & Mustofa, S. 2025. Hubungan Luas Lesi Foto Toraks Pasien Tuberkulosis Paru Dengan Waktu Konversi Sputum Basil Tahan Asam. Jurnal Medika Malahayati, 9(2).
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Copyright (c) 2026 Muhammad Ricky Ramadhian, Sindika Amertavia, Ayu Tiara Fitri, Syazili Mustofa
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