Comparison of the Effectiveness of Hepatoprotectors of Black Cumin Extract and Temulawak Extract in SGOT and SGPT Induced by Paracetamol
DOI:
https://doi.org/10.53366/jimki.v8i2.127Keywords:
IndonesiaAbstract
ABSTRACT
Background: Paracetamol is used for analgesics and antipyretics, its use can damage the liver. Herbs that prevent liver disorders are curcuma. Black cumin can increase antioxidants. Objective: This study aims to compare the effectiveness of black cumin extract and curcuma against the liver function of paracetamol-induced rats. Methods: A laboratory experimental study posttest only with control group design. A total of 4 groups were treated for 7 days. SGOT and SGPT levels were tested. Data analysis using one-way ANOVA post hoc Games-Howell.Results: K- and K+ groups in this study showed an increase in SGOT SGPT levels. There is an effect of giving a dose of paracetamol 500 mg/kgBB on liver damage, there is no differences and significant effect in the administration of black cumin extract and curcuma dose 500 mg/kgBB to the liver of rats that have been induced by paracetamol (p>0.05). Conclusion: Giving paracetamol has an influence on rat liver damage. And there was no difference in the effects of hepatoprotector in groups given black cumin extract and curcuma in paracetamol-induced rats.
Keywords: black cumin, curcuma, paracetamol, SGOT, SGPT
References
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11. Adam GO, Rahman MM, Lee S, et al. Hepatoprotective effects of Nigella sativa seed extract against acetaminophen-induced oxidative stress. Asian Pac J Trop Med. 2016;9(3):221-227.
12. Devaraj S, Ismail S, Ramanathan S, Yam MF. Investigation of Antioxidant and Hepatoprotective Activity of Standardized Curcuma xanthorrhiza Rhizome in Carbon Tetrachloride-Induced Hepatic Damaged Rats. 2014;2014.
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2. Puri SK, Habbu PV, Kulkarni PV, Kulkarni VH. Hepatoprotective Activity Of Fungal Endophytic Fractions Of Andrographis Paniculata (Burm. F.) Wall Nees. Leaves In Paracetamol And Ethanol Induced Hepatotoxicity. Int J Pharm Sci Res. 2019;10(1):97-107.
3. George M, Joseph L, Deshwal N, Joseph J. Hepatoprotective activity of different extracts of Pterospermum acerifolium against paracetamol induced hepatotoxicity in albino rats. 2016;5(3):32-36.
4. Khan MA, Afzal M. Chemical composition of Nigella sativa Linn?: Part 2 Recent advances. Inflammopharmacology. 2016;24(2):67-79.
5. Kazmi A, Khan MA. Biotechnological approaches for production of bioactive secondary metabolites in Nigella sativa?: an up-to-date review. 2019;6(2):172-195.
6. Kushwah D., Salman M., Singh P, Verma V., Ahmad A. Protective Effect of Ethanolic Extract of Nigella Sativa Seed in Paracetamol Induced Acute Hepatotoxicity In vivo. Pakistan J Biol Sci. 2014;17 (4):517-522.
7. Eidi A, Zarin Ghalam J, Rezazade SA, Adeli R. Hepatoprotective effect of Berberis vulgaris L. extract on CCl4-induced toxicity in rats. Trauma Mon. 2011.
8. Hadinata M teguh. Uji Efek Hepatorepair Ekstrak Temulawak (Curcuma Xanthorrhiza Roxb) pada Tikus Putih Jantan Galur Wistar yang diinduksi Paracetamol. 2016.
9. Hayat MA. Autophagy?: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging?: Volume 3 - Role in Specific Diseases. Academic Press; 2013.
10. Eldutar E, Kandemir FM, Kucukler S, Caglayan C. Restorative effects of Chrysin pretreatment on oxidant – antioxidant status , inflammatory cytokine production , and apoptotic and autophagic markers in acute paracetamol-induced hepatotoxicity in rats?: An experimental and biochemical study. 2017;(February):4-9.
11. Adam GO, Rahman MM, Lee S, et al. Hepatoprotective effects of Nigella sativa seed extract against acetaminophen-induced oxidative stress. Asian Pac J Trop Med. 2016;9(3):221-227.
12. Devaraj S, Ismail S, Ramanathan S, Yam MF. Investigation of Antioxidant and Hepatoprotective Activity of Standardized Curcuma xanthorrhiza Rhizome in Carbon Tetrachloride-Induced Hepatic Damaged Rats. 2014;2014.
13. Klarissa C. Uji Efek Pemberian Ekstrak Temulawak (Curcuma Xanthorrhiza Roxb.) terhadap Gambaran Histopatologi Ginjal Tikus Putih Jantan Galur Wistar Yang Diinduksi Parasetamol. 2016.
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2020-08-22
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Research Article
How to Cite
Comparison of the Effectiveness of Hepatoprotectors of Black Cumin Extract and Temulawak Extract in SGOT and SGPT Induced by Paracetamol. (2020). JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia, 8(2), 29-35. https://doi.org/10.53366/jimki.v8i2.127
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