EFFECTIVENESS OF NANO-HYDROXYAPATITE AS A CURATIVE MEASURE FOR OSTEOPOROSIS FRACTURES THROUGH OSTEOINDUCTIVE BONE HEALING (SCAFFOLD) MECHANISM: A SYSTEMATIC REVIEW
Tinjauan Sistematis
DOI:
https://doi.org/10.53366/jimki.v11i2.811Keywords:
Diamond bone healing, Osteoporotic fracture, Nano Hydroxyapatite/nHAp, Osteoinductive, ScaffoldAbstract
Abstract: This study assesses the effectiveness of Nano-Hydroxyapatite (nHAp) in treating fractures related to osteoporosis using experimental animal models based on existing research. The focus is on improving the Quality of Life (QoL) through bone healing mechanisms. Methods: A systematic review employing experimental methods was conducted to induce fractures in animal models with osteoporosis and then treat them with nHAp. Objective: This study aims to evaluate nHAp by measuring clinical and radiological parameters, as well as the histological assessment of the bone healing process. Results: The study found that the use of nHAp significantly improved the bone healing process in animal models. Clinical evaluation demonstrated a notable increase in bone strength due to the impact of immunomodulators. Radiological analysis indicated improved bone regeneration in the nHAp-treated group compared to the control group. At the histological level, there was an increase in the proliferation of osteoblast cells, mineral deposits in the fracture area, and improved flexibility with the scaffold. Conclusion: This study concludes that Nano-Hydroxyapatite (nHAp) is effective as a treatment for osteoporosis-related fractures due to its osteoinductive mechanism. The use of nHAp can accelerate the bone healing process by enhancing the quality of the formed bone, which has the potential to contribute to an improved quality of life for individuals with osteoporosis.
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27. Raucci MG, Demitri C., Soriente A., Fasolino I., Sannino A., Ambrosio L. Perancah hidrogel gelatin/nano-hidroksiapatit dibuat dengan teknologi sol-gel sebagai pengisi untuk memperbaiki kerusakan tulang. J. Biomed. Materi. Res. A.2018?; 106?:2007–2019. doi: 10.1002/jbm.a.36395. [ PubMed ].
28. Zhang JC, Lu HY, Lv GY, Mo AC, Yan YG, Huang C. Perbaikan cacat ukuran kritis dengan nanokomposit hidroksiapatit/poliamida berpori: Sebuah studi eksperimental pada mandibula kelinci. Int. J. Maksilofak Lisan. Bedah. 2010; 39?:469–477. doi: 10.1016/j.ijom.2010.01.013. [ PubMed ].
29. Xiong Y, Mi B Bin, Lin Z, Hu YQ, Yu L, Zha KK, et al. The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity. Vol. 9, Military Medical Research. BioMed Central Ltd; 2022.
30. Mondal S., Dorozhkin SV, Pal U. Kemajuan terkini dalam aplikasi fabrikasi dan pengiriman obat hidroksiapatit berstrukturnano. Interdisipliner Wiley. Pendeta Nanomed. Nanobioteknologi. 2018; 10?:e1504. doi: 10.1002/wnan.1504. [ PubMed ].
31. Chu W., Huang Y., Yang C., Liao Y., Zhang X., Yan M., Cui S., Zhao C. Nanopartikel kalsium fosfat difungsikan dengan polietilen glikol terkonjugasi alendronate (PEG) untuk pengobatan metastasis tulang. Int. J.Pharm. 2017; 516?:352–363. doi: 10.1016/j.ijpharm.2016.11.051. [ PubMed ].
2. Hu X, Ma S, Chen L, Tian C, Wang W. Association between osteoporosis and cardiovascular disease in elderly people: evidence from a retrospective study. PeerJ. 2023 Dec 8;11:e16546. doi: 10.7717/peerj.16546. PMID: 38089913; PMCID: PMC10712301.
3. Lin L, Luo P, Yang M, Wang J, Hou W, Xu P. Causal relationship between osteoporosis and osteoarthritis: A two-sample Mendelian randomized study. Front Endocrinol (Lausanne). 2022 Oct 21;13:1011246. doi: 10.3389/fendo.2022.1011246. PMID: 36339427; PMCID: PMC9633945.
4. IOF. Epidemiology of Osteoporosis. International Osteoporosis Foundation. 2024. .
5. IOF. Epidemiology according to fragility fracture type. International Osteoporosis Foundation. 2024. .
6. Anasulfalah H, Verasita P, Widiyanto A, Atmojo JT. Smoking Behavior and the Incident of Osteoporosis in the. Indones J Glob Heal Res. 2023;5(4):735–42. .
7. Ciancia S, van Rijn RR, Högler W, Appelman-Dijkstra NM, Boot AM, Sas TCJ, Renes JS. Osteoporosis in children and adolescents: when to suspect and how to diagnose it. Eur J Pediatr. 2022 Jul;181(7):2549-2561.
8. Kates SL, Ackert-Bicknell CL. How do bisphosphonates affect fracture healing? Injury. 2016 Jan;47 Suppl 1(0 1):S65-8. doi: 10.1016/S0020-1383(16)30015-8. PMID: 26768295; PMCID: PMC4739649.
9. Abe S, Inoue M, Mikami T, Kanno T, Masuda T. Denosumab-associated Periprosthetic Atypical Femur Fracture: A Case Report. J Orthop Case Rep. 2023 Sep;13(9):29-32. doi: 10.13107/jocr.2023.v13.i09.3864. PMID: 37753145; PMCID: PMC10519314.
10. Ganesan K, Goyal A, Roane D. Bisphosphonate. [Updated 2023 Jul 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470248/.
11. Hildebrand GK, Patel P, Kasi A. Denosumab. [Updated 2024 Feb 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK535388.
12. Andrzejowski P, Giannoudis PV. The “diamond concept” for long bone non-union management. J Orthop Traumatol. 2019 Apr 11;20(1):21. doi: 10.1186/s10195-019-0528-0. PMID: 30976944; PMCID: PMC6459453.
13. Zastulka A, Clichici S, Tomoaia-Cotisel M, Mocanu A, Roman C, Olteanu CD, Culic B, Mocan T. Recent Trends in Hydroxyapatite Supplementation for Osteoregenerative Purposes. Materials (Basel). 2023 Feb 3;16(3):1303.
14. Kattimani VS, Kondaka S, Lingamaneni KP. Hydroxyapatite–-Past, Present, and Future in Bone Regeneration. Bone Tissue Regen Insights. 2016 Jan;7:BTRI.S36138.
15. Hejazi F, Ebrahimi V, Asgary M, Piryaei A, Fridoni MJ, Kermani AA, et al. Improved healing of critical-size femoral defect in osteoporosis rat models using 3D elastin/polycaprolactone/nHA scaffold in combination with mesenchymal stem cells. J Mater Sci Mater Med. 2021 Mar 1;32(3).
16. He Y, Dong Younghai, Cui F, Chen X, Lin R. Osteogenesis dan Perancah Ektopik Biodegradasi Nano- Hidroksipatit- Kitosan dalam Model Tikus. PLOS Jurnal. 2015;1–15.
17. Lv Y, Yu Q. Perbaikan cacat osteochondral artikular pada Sendi Lutut Menggunakan Perancah Pipih Komposit. 2015;4(4).
18. Chatzipetros E, Damaskos S, Tosios KI, Christopoulos P, Donta C, Kalogirou EM, et al. The effect of nano-hydroxyapatite/chitosan scaffolds on rat calvarial defects for bone regeneration. Int J Implant Dent. 2021 Dec;7(1).
19. Dhivya S, Saravanan S, Sastry TP, Selvamurugan N. Nanohydroxyapatite-reinforced chitosan composite hydrogel for bone tissue repair in vitro and in vivo. J Nanobiotechnology. 2015 Jun 12;13(1).
20. Wang G, Roohani-Esfahani SI, Zhang W, Lv K, Yang G, Ding X, et al. Effects of Sr-HT-Gahnite on osteogenesis and angiogenesis by adipose derived stem cells for critical-sized calvarial defect repair. Sci Rep. 2017 Jan 20;7.
21. Ye P, Yu B, Deng J, She RF, Huang WL. Application of silk fibroin/chitosan/nano-hydroxyapatite composite scaffold in the repair of rabbit radial bone defect. Exp Ther Med. 2017 Dec 1;14(6):5547–53.
22. Chatzipetros E, Christopoulos P, Donta C, Tosios KI, Tsi-Ambas E, Tsiourvas D, et al. Application of nano-hydroxyapatite/chitosan scaffolds on rat calvarial critical-sized defects: A pilot study. Med Oral Patol Oral Cir Bucal. 2018 Sep 1;23(5):e625–32.
23. Elghareeb MM, Elshopakey GE, Elkhooly TA, Salama B, Samy A, Bazer FW, et al. Estradiol and zinc-doped nano hydroxyapatite as therapeutic agents in the prevention of osteoporosis; oxidative stress status, inflammation, bone turnover, bone mineral density, and histological alterations in ovariectomized rats. Front Physiol. 2022 Sep 19;13.
24. Zhou Y, Hu Z, Ge M, Jin W, Tang R, Li Q, et al. Intraosseous injection of calcium phosphate polymer-induced liquid precursor increases bone density and improves early implant osseointegration in ovariectomized rats. Int J Nanomedicine. 2021;16:6217–29.
25. Barbeck M, Jung O, Smeets R, Gosau M, Schnettler R, Rider P, et al. Implantation of an injectable bone substitute material enables integration following the principles of guided bone regeneration. In Vivo (Brooklyn). 2020;34(2):557–68.
26. Wang DX, He Y, Bi L, Qu ZH, Zou JW, Pan Z, et al. Enhancing the bioactivity of Poly(lactic-co-glycolic acid) scaffold with a nano-hydroxyapatite coating for the treatment of segmental bone defect in a rabbit model. Int J Nanomedicine. 2013 May 8;8:1855–65.
27. Raucci MG, Demitri C., Soriente A., Fasolino I., Sannino A., Ambrosio L. Perancah hidrogel gelatin/nano-hidroksiapatit dibuat dengan teknologi sol-gel sebagai pengisi untuk memperbaiki kerusakan tulang. J. Biomed. Materi. Res. A.2018?; 106?:2007–2019. doi: 10.1002/jbm.a.36395. [ PubMed ].
28. Zhang JC, Lu HY, Lv GY, Mo AC, Yan YG, Huang C. Perbaikan cacat ukuran kritis dengan nanokomposit hidroksiapatit/poliamida berpori: Sebuah studi eksperimental pada mandibula kelinci. Int. J. Maksilofak Lisan. Bedah. 2010; 39?:469–477. doi: 10.1016/j.ijom.2010.01.013. [ PubMed ].
29. Xiong Y, Mi B Bin, Lin Z, Hu YQ, Yu L, Zha KK, et al. The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity. Vol. 9, Military Medical Research. BioMed Central Ltd; 2022.
30. Mondal S., Dorozhkin SV, Pal U. Kemajuan terkini dalam aplikasi fabrikasi dan pengiriman obat hidroksiapatit berstrukturnano. Interdisipliner Wiley. Pendeta Nanomed. Nanobioteknologi. 2018; 10?:e1504. doi: 10.1002/wnan.1504. [ PubMed ].
31. Chu W., Huang Y., Yang C., Liao Y., Zhang X., Yan M., Cui S., Zhao C. Nanopartikel kalsium fosfat difungsikan dengan polietilen glikol terkonjugasi alendronate (PEG) untuk pengobatan metastasis tulang. Int. J.Pharm. 2017; 516?:352–363. doi: 10.1016/j.ijpharm.2016.11.051. [ PubMed ].
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EFFECTIVENESS OF NANO-HYDROXYAPATITE AS A CURATIVE MEASURE FOR OSTEOPOROSIS FRACTURES THROUGH OSTEOINDUCTIVE BONE HEALING (SCAFFOLD) MECHANISM: A SYSTEMATIC REVIEW: Tinjauan Sistematis. (2025). JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia, 11(2), 30-47. https://doi.org/10.53366/jimki.v11i2.811
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