The Use of Prophylaxic Antibiotics in Patients with Caesarean Section in the Inpatient Installation of Cibinong Regional General Hospital in the Period of January - December 2023
DOI:
https://doi.org/10.53366/jimki.v12i2.912Keywords:
Cesarean Section, Prophylactic AntibioticsAbstract
Background: Postoperative infections after cesarean section (CS) remain a major concern, increasing morbidity, hospitalization duration, and healthcare costs. Prophylactic antibiotics are an important preventive measure, but their effectiveness depends on appropriate type, dose, timing, and adherence to guidelines. This study evaluated prophylactic antibiotic use in CS patients at Cibinong Regional General Hospital (RSUD).
Methods: A descriptive cross-sectional study analyzed medical records of 81 CS patients from January to December 2023. Data on antibiotic type, dose, timing, and clinical outcomes were assessed against hospital, POGI, and ASHP guidelines.
Results: All patients received prophylactic antibiotics. Cefazolin was most commonly used (61.7%) and showed the highest effectiveness, with no infections among 50 patients. In contrast, ampicillin, gentamicin, and metronidazole were less effective, with infection rates of 26.7%, 100%, and 100%, respectively. Overall, 24.7% of patients developed postoperative infections.
Discussion: Findings highlight cefazolin’s superiority, consistent with international guidelines recommending it as first-line prophylaxis for CS. Variations in antibiotic selection, dosing, and timing were linked to higher infection rates, emphasizing that protocol inconsistencies reduce effectiveness. Risk factors such as maternal age, obstetric history, and indication for CS may also influence outcomes.
Conclusion: Prophylactic antibiotic use at Cibinong RSUD generally followed guidelines, with cefazolin proving most effective. However, inconsistent practices in dosage and timing contributed to a notable infection rate, underscoring the need for stricter adherence to standards.
References
1. Betran Ap, Ye J, Moller Ab, Souza Jp, Zhang J. Trends And Projections Of Caesarean Section Rates: Global And Regional Estimates. Bmj Glob Health 2021;6(6).
2. Angolile Cm, Max Bl, Mushemba J, Mashauri Hl. Global Increased Cesarean Section Rates And Public Health Implications: A Call To Action. Health Sci Rep 2023;6(5).
3. Hall C, Allen J, Barlow G. Antibiotic Prophylaxis. Surgery (United Kingdom). 2015;33(11).
4. WHO. Prophylactic Antibiotics For Women Undergoing Caesarean Section. 2021;
5. Widya Pratiwi R, Simanjuntak Yy, Rika Veriyanti P. Evaluasi Penggunaan Antibiotik Profilaksis Pada Pasien Sectio Caesarea Di Rsud Budhi Asih Periode Juni-Desember 2020. 2023;16(1).
6. Novietaningtyas W, Kurniasih S, Fhatonah N. Evaluasi Penggunaan Obat Antibiotik Profilaksis Pada Pasien Operasi Sesar (Sectio Caesarea) Di Rsud Kabupaten Tangerang Tahun 2018. Jurnal Farmagazine 2020;7(2):68.
7. Maelaningsih Fs, Fahriati Ar, Agung D, Et Al. Evaluasi Penggunaan Antibiotik Profilaksis Pada Pasien Section Caesarea Di Rumah Sakit Swasta Tangerang Selatan Evaluation The Use Of Antibiotic Prophylaxis In Caesarean Section Patients At A Private Hospital South Tangerang. 2020;
8. Fifin Oktaviani, Djoko Wahyono, Endang Yuniarti. Evaluasi Penggunaan Antibiotik Profilaksis Terhadap Kejadian Infeksi Luka Operasi Pada Operasi Sectio Caesarea. 2015;
9. Dhole S, Mahakalkar C, Kshirsagar S, Bhargava A. Antibiotic Prophylaxis In Surgery: Current Insights And Future Directions For Surgical Site Infection Prevention. Cureus 2023;
10. Julian A, Prihadi Jc, S Indrajaya Ys. The Prevalence Of Lower Urinary Tract Symptoms In Caesarean Section Patients’ First And Seventh Day Of Postpartum Perbandingan Prevalensi Gejala Saluran Kemih Bawah Pada Ibu Postpartum Hari Pertama Dan Hari Ketujuh Secara Sectio Caesarea. 2023;
11. Zielda Najib S, Setiawan Wibowo T, Farmasi Yannas Husada Bangkalan A, Stie Mahardhika I. Evaluation Of Antibiotic Prophylaxis In C-Section Patients At Rsia Hikmah Sawi. Journal Of International Multidisciplinary Research [Homepage On The Internet] 2024;Available From: Https://Journal.Banjaresepacific.Com/Index.Php/Jimr
12. Brocard E, Reveiz L, Régnaux Jp, Abdala V, Ramón-Pardo P, Bueno A Del R. Antibiotic Prophylaxis For Surgical Procedures: A Scoping Review. Revista Panamericana De Salud Publica/Pan American Journal Of Public Health. 2021;45.
13. Igwemadu Gt, Eleje Gu, Eno Ee, Et Al. Single-Dose Versus Multiple-Dose Antibiotics Prophylaxis For Preventing Caesarean Section Postpartum Infections: A Randomized Controlled Trial. Women’s Health 2022;18.
14. Gan A, Khursheed R, Savanur M, Dalal A, Maldar A. The Impact Of An Evidence-Based Bundle On Cesarean Section-Related Surgical Site Infections: A Randomized Clinical Trial. Maternal-Fetal Medicine 2024;6(2):70–77.
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