The Effectiveness of Polydeoxyribonucleotide (PDRN) from Salmo salar Administered via Microneedling versus Topical Serum for Anti-Aging Therapy

Abstract

The use of polydeoxyribonucleotide (PDRN) has recently gained attention as an anti-aging skin treatment. Initially, PDRN treatments were more commonly performed in aesthetic clinics using microneedling techniques. However, the beauty industry has recently developed PDRN-based moisturizers that are easier for daily use and are often promoted as products containing salmon-derived DNA. PDRN is known to activate the adenosine A2A receptor, which promotes collagen synthesis, accelerates tissue repair, and provides anti-inflammatory effects. This study aimed to compare the efficacy and safety of PDRN administration through microneedling and topical application for anti-aging purposes. A systematic review was conducted of experimental and clinical studies reporting outcomes on wound healing, skin texture, elasticity, and side effects. The analysis showed that both methods effectively improved skin quality with minimal adverse reactions. Microneedling enhanced intradermal penetration, accelerated tissue regeneration, and stimulated collagen and elastin synthesis more rapidly; meanwhile, topical PDRN reduced oxidative stress and improved skin tone, with effects being particularly significant when combined with vitamin C or niacinamide. Overall, both methods are safe and effective for anti-aging therapy. Microneedling offers faster collagen regeneration, whereas topical PDRN serum provides a practical and non-invasive alternative. The choice of treatment should be tailored to patient preference, skin condition, and pain tolerance.