Effects Of Prolonged Continuous Theta Burst Stimulation On Corticospinal And Intracortical Function In Diabetic Neuropathy
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- Abstract
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Introduction: Diabetic neuropathy (DN) is a common chronic complication of diabetes mellitus characterized by damage to the peripheral and central nervous systems due to prolonged hyperglycemia. This condition leads to neuropathic pain, sensory impairment, motor dysfunction, and reduced quality of life. Current treatments are largely symptomatic and have limited effectiveness in restoring nerve function, highlighting the need for innovative non-invasive therapies.
Method: This study employed a narrative literature review design with a systematic search of Google Scholar academic search engine and the PubMed and ScienceDirect databases. Article selection was conducted through identification, screening, and eligibility assessment based on predefined inclusion and exclusion criteria. Six relevant studies were included and analyzed qualitatively to synthesize the main findings regarding the effectiveness of prolonged continuous theta burst stimulation (pcTBS).
Discussion: The findings indicate that pcTBS targeting the primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) enhances corticospinal excitability, as evidenced by increased motor evoked potential (MEP) amplitude, and strengthens intracortical inhibition through GABAergic mechanisms. These neurophysiological changes are associated with reduced neuropathic pain, improved motor function, and better quality of life. Additionally, pcTBS demonstrates a favorable safety profile with minimal adverse effects.
Conclusion: pcTBS shows promise as a non-invasive neuromodulation therapy and an effective adjuvant approach for reducing neuropathic pain and improving motor function in patients with diabetic neuropathy, supporting its potential application in clinical practice.
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- 2026-08-31
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