CIRCULATING MICRORNAS AS A NOVEL BIOMARKER FOR DIAGNOSIS OF ACUTE ISCHEMIC STROKE PATIENTS: A SYSTEMATIC REVIEW

Abstract

 ABSTRACT

Background: Acute ischemic stroke (AIS) is the types of stroke with the highest incidence, especially in the elderly group. Nowadays, neuroimaging is the main modality in stroke diagnosis, but it still has several drawbacks, such as limited, high cost, long time for the procedure, and in some cases, the results of image interpretation are often inconsistent in the early stroke phase. Therefore we need a fast, precise, and simple diagnostic tool for the diagnosis of AIS. Currently, certain types of circulating microRNA (miRNA) can be biomarker for AIS diagnostics. The goal of this study is to profiling as well as evaluate the diagnostic value of circulating miRNA in AIS patients, hemorrhagic stroke (HS) patients, and healthy individuals.

Methods: This systematic review collects literatures from PubMed, Science Direct, Directory of Open Access Journal (DOAJ), Clinical Trials.gov, and Epistemonikos using standardized methods by cochrane guideline for systematic review to evaluate the diagnostic value of circulating MiRNAs as biomarkers for AIS by its sensitivity, specificity, and Area Under the Curve (AUC) score.

Discussion: Out of 870 studies, 15 studies matched the inclusion criteria. The studies that reviewed showed that hsa-miR-106b-5P and the combination of miR-125a-5p + miR-125b-5p + miR-143-3p are the most effective types of miRNA as biomarkers in diagnosing AIS and differentiating it from healthy individuals. Meanwhile, miR-124-3p is the most effective type as a biomarker to differentiate AIS and HS.

Conclusion: Circulating miRNA isolated from human plasma, serum, and blood can be used as a diagnostic biomarker for AIS.

Keyword: acute ischemic stroke, circulating microRNAs, diagnostic